The Sinclair Method (TSM) is a treatment for alcohol use disorder (AUD) that uses an opiate blocker to reduce or eliminate a person's craving for alcohol. It's time to change the things we can no longer accept, using science and medicine to treat alcohol use disorder.


About 10 percent of those using TSM become 100% abstinent


Long-term success rate with the Sinclair Method


Months for most TSM users to reach 'extinction'

How I Overcame Alcoholism

Claudia Christian | TEDx London Business School | April 29, 2016


Global Sinclair Method Awareness Day

May 17, 2019

Get involved in our first ever day of spreading TSM around the world – June 12, 2019 On June 12, 2019 the C Three Foundation is celebrating six years of operation with the inaugural Global Sinclair Method Awareness Day and we are offering you the opportunity to participate. Below are ways you can get involved…


Alcohol Rewards and the Sinclair Method

Jan 17, 2019

When most people think about the reward from drinking alcohol, one of the first things that comes to mind is the “buzz” or intoxicating effects. With that in mind, some people new to the Sinclair Method (TSM) begin with the expectation that they will take their medication and it will keep them from getting drunk.…


Navigating Dry January While on the Sinclair Method

Jan 7, 2019

Every January we hear the same question – “Should I attempt Dry January (or ‘Dryuary’ as it is also known) while I’m on the Sinclair Method (TSM)?” The Good There are many benefits to beginning a new year without alcohol. If you have wined, dined, and celebrated your way though the holiday season, abstaining from…


Tracking Drinks: Standard Units of Alcohol

Dec 11, 2018

One of the simplest concepts in alcohol reduction and moderation, tracking one’s alcohol-containing drinks, can also be one of the most confusing to understand. Perhaps part of the confusion comes from the often touted and complete oversimplification of one shot = one beer = one glass of wine. Unfortunately, this one equation could be part…


How Telemedicine Is Changing Alcohol Treatment

Nov 19, 2018

People who are ready to reduce or eliminate their alcohol intake are increasingly turning to telemedicine. But not everyone understands what telemedicine is or how convenient it is to use. The C Three Foundation has partnered with Ria Health to explain telemedicine, why it is quickly becoming one of the most popular ways to see…


Answers to the TSM Basics Quiz

Nov 7, 2018

  We ran an 8-question quiz testing your knowledge about Sinclair Method basics. We had 101 responses with an overall average score of 86%. Below are the 8 questions and the expanded answers. Did you take the quiz? How did you do?  


Separating Myth from Fact: Naltrexone effective time and re-dosing

Oct 31, 2018

Recently, there has been a lot of confusion about the effective time period for a standard dose of naltrexone and we want to set the record straight. We’ve noticed an increased amount of misinformation that is not based on the existing body of research or knowledge of this medication. Further clouding the situation, C Three…


TSM: Hacking alcohol recovery

Oct 12, 2018

It seems everybody loves a good life hack. Human beings have a tendency to pack way too much into an average day, so anything we can do streamline our lives and reclaim time can feel like a miracle. In this respect, recovery from alcohol use disorder is not much different. We’ve compiled some tips that…



An estimated 3 out of 10 American adults struggle with alcohol use disorder. Many don't get help because of a $35 billion 'one size fits all' treatment industry that often demeans and vilifies the very people it claims to help. The C Three Foundation is changing the conversation about alcohol use, misuse, and treatment. It's time to change the things we can no longer accept, using science and compassion. Please donate today.


We know you do your best every day to help your patients get healthy and stay healthy. It isn’t always easy to talk to your patients about their alcohol use, even though harmful alcohol use can significantly, adversely affect health. We want to help you and your patients change the conversation about harmful alcohol use.

For decades, alcohol misuse has traditionally been treated as a moral failing resulting in shame, stigma, and chronic treatment failure. As a medical professional, you understand the physical, medical harm alcohol abuse can cause and you also understand that medication-assisted treatment is a science-based option all patients deserve to be offered.

You do not have to be an addiction specialist to screen and treat your patients. Click below to be directed to our site designed specifically for medical professionals, where you can find information and resources to more effectively treat your patients who have been diagnosed with alcohol use disorder.