The Sinclair Method (TSM) is a treatment for alcohol use disorder (AUD) that uses an opiate blocker to reduce or eliminate a person's craving for alcohol. It's time to change the things we can no longer accept, using science and medicine to treat alcohol use disorder.


About one quarter of those using TSM become 100% abstinent


Long-term success rate with the Sinclair Method


Months for most TSM users to reach 'extinction'

How I Overcame Alcoholism

Claudia Christian | TEDx London Business School | April 29, 2016


Answers to the TSM Basics Quiz

Nov 7, 2018

  We ran an 8-question quiz testing your knowledge about Sinclair Method basics. We had 101 responses with an overall average score of 86%. Below are the 8 questions and the expanded answers. Did you take the quiz? How did you do?  


Separating Myth from Fact: Naltrexone effective time and re-dosing

Oct 31, 2018

Recently, there has been a lot of confusion about the effective time period for a standard dose of naltrexone and we want to set the record straight. We’ve noticed an increased amount of misinformation that is not based on the existing body of research or knowledge of this medication. Further clouding the situation, C Three…


TSM: Hacking alcohol recovery

Oct 12, 2018

  It seems everybody loves a good life hack. Human beings have a tendency to pack way too much into an average day, so anything we can do streamline our lives and reclaim time can feel like a miracle. In this respect, recovery from alcohol use disorder is not much different. We’ve compiled some tips…


TSM Drink Log: Android App Download

Feb 20, 2018

How can you “drink responsibly” if you don’t know how much alcohol you are really drinking? Warnings about harmful alcohol use typically use “standard units.” That can be confusing to most people, who are not going to take the time to convert alcohol by volume (ABV%) and ounces or milliliters into these standard units. Track…


Drink Yourself Sober

Jul 20, 2017

A guest post written by Patrick McNichol (used with permission) 88,000. That’s equivalent to twenty-nine 9/11 terrorist attacks. It’s about one person in the Buffalo Metro every day. This is how many people die as a result of Alcohol Use Disorder (AUD) in the US each year, according to the National Institute of Alcoholism and…


A Questionable Double Standard

Jun 28, 2017

Note: This article is not meant to debate the issue of whether or not an individual of any age should or should not get an annual flu vaccine. The sole intention is to bring attention to a clear double standard that exists. Personal medical decisions are between you and your doctor. It can be frustrating…


Drink Reduction Over Time

May 30, 2017

The C Three Foundation conducted a random, anonymous survey of 100 people using the Sinclair Method (TSM). People were invited to participate through email, social media, and the Options Save Lives forum. While we will unveil all of the results and insights on June 12, 2017 to celebrate four years of helping people achieve lasting…


In search of doctors…

Apr 27, 2017

In spite of our recent success in dramatically expanding the number of Verified TSM Professionals that we have listed on our Find a Physician page, there is still much work to be done. This week, we’ve had 2 medical professionals tell us they are treating people who travel from out of state to see them.…



An estimated 3 out of 10 American adults struggle with alcohol use disorder. Many don't get help because of a $35 billion 'one size fits all' treatment industry that often demeans and vilifies the very people it claims to help. The C Three Foundation is changing the conversation about alcohol use, misuse, and treatment. It's time to change the things we can no longer accept, using science and compassion. Please donate today.


We know you do your best every day to help your patients get healthy and stay healthy. It isn’t always easy to talk to your patients about their alcohol use, even though harmful alcohol use can significantly, adversely affect health. We want to help you and your patients change the conversation about harmful alcohol use.

For decades, alcohol misuse has traditionally been treated as a moral failing resulting in shame, stigma, and chronic treatment failure. As a medical professional, you understand the physical, medical harm alcohol abuse can cause and you also understand that medication-assisted treatment is a science-based option all patients deserve to be offered.

You do not have to be an addiction specialist to screen and treat your patients. Click below to be directed to our site designed specifically for medical professionals, where you can find information and resources to more effectively treat your patients who have been diagnosed with alcohol use disorder.