About the Sinclair Method

The Sinclair Method (TSM) is a treatment for alcohol addiction that uses a technique called pharmacological extinction—the use of an opiate blocker to turn habit-forming behaviors into habit-erasing behaviors. The effect returns a person’s craving for alcohol to its pre-addiction state.

TSM consists of taking an opiate blocker one hour before your first drink of the day for the rest of your life as long as you continue to drink. The opiate blocker chemically disrupts the body’s behavior/reward cycle causing you to want to drink less instead of more.

The Sinclair Method has a 78% long-term success rate.*

Studies have proven that TSM is equally effective with or without therapy, so patients can choose whether or not to combine TSM with therapy. The physical results will be the same.** Extinction usually occurs within 3-4 months.***

About one quarter of those on TSM become 100% abstinent. Those who continue to drink will have to take their medication prior to drinking for as long as they continue to drink.


*Most other treatments claim a 5-15% success rate.  **All other treatments for alcohol dependency fall into one of three categories: attempting to manage the desire to drink; chemically suppressing the craving to drink, like a diet pill; or making drinking so miserable the person doesn't want to drink anymore. ***As with any medical treatment, patient results may vary. Dosage changes should be discussed with a physician.