Science of the Sinclair Method

Peer-reviewed Research and Writings by J. David Sinclair, PhD

Peer-reviewed Studies

  • Kranzler, H. R., Tennen, H., Armeli, S., Chan, G., Covault, J., Arias, A., & Oncken, C. (2009). Targeted naltrexone for problem drinkers. Journal of Clinical Psychopharmacology, 29(4), 350–357.
  • Heinälä, P., H. Alho, K. Kiianmaa, J. Lönnqvist, K. Kuoppasalmi, and J. D. Sinclair. Targeted use of naltrexone without prior detoxification in the treatment of alcohol dependence: A factorial double-blind placebo-controlled trial. Journal of Clinical Psychopharmacology: 21(3): 287-292, 2001.
  • Grant BF, Saha TD, Ruan WJ, et al. Epidemiology of DSM-5 Drug Use Disorder Results From the National Epidemiologic Survey on Alcohol and Related Conditions–III. JAMA Psychiatry. 2016;73(1):39–47. doi:10.1001/jamapsychiatry.2015.2132
  • Jonas DE, Amick HR, Feltner C, et al. Pharmacotherapy for Adults With Alcohol Use Disorders in Outpatient Settings: A Systematic Review and Meta-analysis.JAMA. 2014;311(18):1889-1900. doi:10.1001/jama.2014.3628.
  • Pettinati HM, Anton RF, Willenbring ML. The COMBINE Study—: An Overview of the Largest Pharmacotherapy Study to Date for Treating Alcohol Dependence. Psychiatry (Edgmont). 2006;3(10):36-39.
  • Foa EB, Yusko DA, McLean CP, et al. Concurrent Naltrexone and Prolonged Exposure Therapy for Patients With Comorbid Alcohol Dependence and PTSDA Randomized Clinical Trial. JAMA. 2013;310(5):488–495. doi:10.1001/jama.2013.8268
  • Darren R. Quelch et al. Nalmefene Reduces Reward Anticipation in Alcohol Dependence: An Experimental Functional Magnetic Resonance Imaging Study, Biological Psychiatry (2017). doi: 10.1016/j.biopsych.2016.12.029

News and Trade Publications

Recent Updates:

Longer Use of Alcohol Use Disorder Medication Reduces Odds of Negative Health Outcomes

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Information From Government Agencies

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SAMHSA - Evidence for the Efficacy of Naltrexone in the Treatment of Alcohol Dependence (Alcoholism)

The National Center for Biotechnology Information: Incorporating Alcohol Pharmacotherapies Into Medical Practice

BC Emergency Medicine Network: Point-of-Care Emergency Clinical Summary, Alcohol Use Disorder (British Columbia, Canada)

Reference Documents

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Annotated Bibliography for Physician

BNSSG Health Community’s Traffic Light System

Evidence About the Use of Naltrexone

2012 European Congress of Psychiatry on Selincro™

Therapeutic Drug Monitoring and the Clinical Significance of Naltrexone Blood Levels at the Time of a First Drink: Relevance to the Sinclair Method